AGENDA
Advanced Technology Consortium (ATC)
Steering Committee - Annual Meeting
April 3, 2006
Conference Room G in the EPN
bldg,
Presentations
(in PDF format) are available from links below.
Some PDF documents are large and may be easier to view by downloading
the PDF files (see note below).
A ZIP archive (7.3 Mb) containing all presentations can be downloaded here.
9:00 AM Opening remarks and introduction to agenda - J. Deye, Project Officer (501 Kb)
9:15 AM PI overview of ATC efforts including ITC - J. Purdy (1.4 Mb)
9:45 AM caBIG In Vivo Image Workspace – D. Kupferschmid (2.4 Mb)
10:15 AM Use of PET in RT Trials: re RTOG 0522 – C. Jaffe (985 Kb)
10:45 AM BREAK
11:00 AM IGRT and NCI Clinical Trials - C. Ling (86 Kb)
11:15 PM ATC Support of NSABP B39/RTOG 0413: A User’s Perspective – F Vicini
11:30 AM QARC subcontract summary - T.J Fitzgerald (1.2 Mb)
11:45 AM RTOG subcontract summary - W. Curran (211 Kb)
12:00 PM RPC subcontract summary - G. Ibbott (1.6 Mb)
12:15 PM RCET subcontract summary - J. Palta (1.3 Mb)
12:30 PM Working lunch
1:15 PM Roundtable discussion of the integration of the ATC into the broader framework of data submission, QA, archiving and retrieval in support of clinical trials
2:30 PM Feedback from the Steering Committee Members
3:00 PM ADJOURN
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Some Abbreviations
ATC - Advanced Technology Consortium cooperative agreement supported by NCI, DCTD, RRP
ITC - Image-guided Therapy QA Center, Wash
CIP - Cancer Imaging Program NCI
QARC -
RTOG - Radiation Therapy Oncology Group,
RPC - Radiological
RCET -
ACRIN - ACR Imaging Network,
ATC Steering Committee:
A Olch - COG
B. Lustig - RTOG
M. Vannier - ACRIN
R. Marcus - COG
J. Bogart - CALGB
P. Okunieff - SWOG
F. Vicini
B. Curran - AAPM
S. Saxman - CTEP
Additional participants:
C. Jaffe - CIP
G. Dorfman - CIP
C. Ling - MSKCC
M. Deering - caBIG
ATC MISSION STATEMENT (http://atc.wustl.edu/index.html)
To facilitate the conduct of National Cancer Institute sponsored advanced technology radiation therapy clinical trials that require digital data submissions while maintaining patient confidentiality. This effort includes radiation therapy quality assurance, image and radiation therapy digital data management, and clinical research and developmental efforts. We strongly believe that advanced medical informatics can facilitate education, collaboration, and peer review, as well as provide an environment in which clinical investigators can receive, share, and analyze volumetric multimodality treatment planning and verification (TPV) digital data. Our ultimate goal is to improve the standards of care in the management of cancer by improving the quality of clinical trials medicine.
Objectives:
* Serve as an educational and developmental resource to the nation's clinical trial cooperative groups and participating institutions for support of advanced technology radiation therapy clinical trials:
* Develop electronic data exchange mechanisms of treatment planning and verification (TPV) data between the ATC QA Centers and the protocol participating institutions, and between the ATC members and cooperative group Operations, Statistics, and Data Management Section(s).
* Develop software tools to facilitate QA reviews by RTOG, QARC, and RPC of TPV data submitted by institutions participating in cooperative group clinical trials (both pediatric and adult) that utilize advanced technologies, including 3DCRT, IMRT, and brachytherapy. Emphasis is on the development and improvement of web-based remote-review tools that allow for the efficient review of centrally located image-based data by reviewers not co-located with these data.
* Develop an archival TPV database for the advanced treatment modalities that can be linked with the cooperative group’s clinical outcomes database.
* Provide expertise in the areas of protocol design, credentialing, monitoring, and analysis for new clinical trials that utilize advanced technologies and require digital data submission, with the intent to ensure uniformity of guidelines;
* Facilitate protocol credentialing, digital data submissions, QA reviews, and outcome analysis.
ATC PRIORITY LIST (as of January 19, 2006)
ATC Service Priorities
1. Provide daily operational support to institutions participating in cooperative group protocols (RTOG, NSABP, JCOG) utilizing advanced technology and requiring digital data submission using ATC Method 1. See ATC website for protocol details. This service effort includes the following: (a) evaluate, approve, and notification regarding institution’s credentialing tests for each specific protocol; (b) facilitate and perform QA reviews of submitted data including integrity of digital data submissions; target volumes, organs at risk, and dose distribution protocol compliance; and (c) maintain QA and treatment planning databases.
2. Provide operational support for the use of ATC Method 1 technology at QARC and increase use of this technology by other cooperative groups, i.e., COG, SWOG, and CALGB.
3. Provide expertise in the areas of protocol design, credentialing, monitoring, and analysis for new clinical trials that utilize advanced technologies and require digital data submission (e.g., NSABP B-39/RTOG 0413). The effort includes the following: (a) develop credentialing tests and criteria (including periodic review/modification of existing requirements/criteria); (b) design/manufacture phantoms for credentialing; (c) develop QA procedures, documents, criteria, and ATC web page/links; develop new protocol module for TPV and QA databases
4. Facilitate outcome analysis and data mining for ATC supported closed protocols.
5. Provide support to NCIC in their use of ATC Method 3 technology for MA.20 protocol.
6. Foster implementation of ATC compliant DICOM export capability. This includes the following: (a) working with radiation treatment planning systems (TPS) vendors; specifically, ATC will target TPSs manufactured by BrainLab, Radionics, Elekta Gamma Knife, TomoTherapy Hi-ART, Cyber-Knife systems, and Prowess; (b) ATC representation in NEMA/DICOM Working Group 7; and (c) ATC representation in the IHE initiative.
ATC Developmental Priorities
1. Increase number of publications referencing ATC NIH U24 grants CA 86147.
2. Develop/implement QA process for protocols requiring multi-modality imaging (PET, MRI, Image fusion).
3. Develop ATC consensus on credentialing requirements for the use of IMRT for intra-thoracic treatments, in which significant heterogeneities are encountered and tumor mobility is likely.
4. Develop/implement brachytherapy QA software to facilitate RPC support of clinical trials. (See current time line for this work).
5. Develop, test, and implement ATC Method 2b technology at NCIC. (See current time line for this work).
6. Develop, test, and implement ATC Method 2a technology at ITC. (See current time line for this work).
ATC Challenges/Opportunities
* Workload at ITC
* ATC compliant stereotactic radiosurgery or radiotherapy RTP systems
* PET (quantitative) data import and image fusion QA
*
* Image-Guided RT protocols (EPID, MV and kVp Cone beam CT, Helical Tomotherapy megavoltage CT)
* Adaptive Radiation Therapy Protocols (Daily Confirmation/Adjustment using On-Board Imaging)
* Increased use of ATC Method 1 at QARC
* Successful implementation of ATC Method 2a at ITC and 2b at NCIC
* Move of ATC effort toward integration with industry informatics efforts
* caBIG compliant software
* RTOG Grant Renewal/ATC Grant Renewal 2007